Several strategies can be employed to overcome limited substrate scope:
Ligand modification: Altering the ligands around the catalyst can help accommodate a broader range of substrates. Reaction conditions: Optimizing parameters such as temperature, pressure, and solvent can enhance the catalyst's substrate tolerance. Catalyst design: Developing new catalysts with improved properties or multifunctionality can expand the substrate scope. Additives: Using co-catalysts or additives can sometimes enhance the catalyst's performance with diverse substrates.
