How are Proteasome Inhibitors Related to Catalysis?
The relationship between proteasome inhibitors and catalysis is intrinsic, as the proteasome itself is a highly specialized catalytic machine. Understanding the catalytic mechanisms of the proteasome's various active sites is crucial for designing effective inhibitors. Techniques such as X-ray crystallography and cryo-electron microscopy have provided detailed insights into the structure and function of the proteasome, aiding in the rational design of inhibitors that can precisely target specific catalytic activities.
