Can Pyrrolysine be Incorporated into Synthetic Proteins?
Yes, pyrrolysine can be incorporated into synthetic proteins using genetic engineering techniques. By introducing the necessary genetic machinery, such as the genes encoding pyrrolysine-tRNA synthetase and the corresponding tRNA, scientists can incorporate pyrrolysine into proteins in heterologous expression systems like E. coli. This enables the exploration of novel catalytic activities and the development of proteins with enhanced or unique functions.
