What role does PDB play in drug discovery related to catalysis?
In drug discovery, understanding the structure of enzyme targets is crucial for designing effective inhibitors. PDB provides the structural data needed to identify binding sites and design molecules that can inhibit enzyme activity. This is particularly important for developing drugs that target catalytic enzymes involved in disease pathways. Structural insights from PDB can inform the design of more potent and selective inhibitors, reducing off-target effects.
