Aspartate transcarbamoylase (ATCase) is an enzyme that plays a crucial role in the biosynthesis of pyrimidine nucleotides. It catalyzes the first committed step in the synthesis of the pyrimidine ring, which is the formation of carbamoyl aspartate from carbamoyl phosphate and aspartate. This enzyme is essential for the synthesis of cytosine, thymine, and uracil nucleotides.
