Apolipoprotein C-II (ApoC-II) is a small protein found in the bloodstream that plays a crucial role in lipid metabolism. It is primarily associated with very-low-density lipoproteins (VLDL) and high-density lipoproteins (HDL). ApoC-II acts as an essential cofactor for the enzyme lipoprotein lipase (LPL), which is critical for the hydrolysis of triglycerides in lipoproteins.