The Sabatier Group faced several challenges in their pioneering work: 1. Catalyst Deactivation: One of the main challenges was preventing catalyst deactivation, which occurs when catalysts lose their activity over time. 2. Selectivity: Achieving high selectivity for desired products while minimizing undesired side reactions was another significant challenge. 3. Scalability: Translating laboratory-scale reactions to industrial-scale processes required overcoming numerous technical hurdles.