What Challenges are Associated with Phosphine Based Organocatalysts?
Despite their many advantages, there are some challenges associated with phosphine based organocatalysts: - Air and Moisture Sensitivity: Many phosphine compounds are sensitive to air and moisture, requiring inert atmosphere techniques. - Limited Substrate Scope: The effectiveness of these catalysts can be limited to specific substrates, necessitating the development of new catalyst designs for broader applicability. - Cost and Availability: Some phosphine ligands and catalysts can be expensive or challenging to synthesize on a large scale.
