complex i (nadh:quinone oxidoreductase)

What are the Therapeutic Implications of Modulating Complex I Activity?

Given its central role in cellular metabolism and disease, modulating Complex I activity holds therapeutic potential. For instance, certain mitochondrial-targeted antioxidants aim to reduce ROS production by stabilizing electron flow through Complex I. Moreover, pharmacological agents that enhance Complex I activity are being explored to treat mitochondrial disorders and improve metabolic health.

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