What are the Mechanisms Involved in RNase P Catalysis?
The catalytic mechanism of RNase P involves a series of complex interactions between the RNA subunit, the protein subunit, and the pre-tRNA substrate. The RNA subunit employs metal ions, typically magnesium, to facilitate the cleavage reaction. These metal ions help to stabilize the transition state and lower the activation energy required for the reaction, thus enhancing the catalytic efficiency.
