What are the Diseases Associated with Complex II Dysfunction?
Defects in Complex II are linked to a variety of diseases: - Hereditary Paragangliomas and Pheochromocytomas: Mutations in SDHB, SDHC, or SDHD genes are associated with these tumors. - Mitochondrial Diseases: Deficiencies in Complex II can lead to a broad spectrum of mitochondrial disorders. - Cancer: Altered function of Complex II is observed in some types of cancer due to its role in regulating apoptosis and cell proliferation.