Despite its advantages, operando MS faces several challenges:
1. Complexity of Setup: The integration of a mass spectrometer with a reaction chamber requires careful design to ensure that the reaction conditions are not altered. 2. Data Interpretation: The analysis of complex spectra, especially when dealing with transient species and intermediates, can be challenging. 3. Sensitivity and Selectivity: Ensuring that the mass spectrometer can detect all relevant species with high sensitivity and selectivity.
