What are the Challenges in Using HPLC for Catalysis?
Despite its advantages, HPLC presents certain challenges: 1. Complex Sample Matrices: Catalytic reactions often produce complex mixtures with many components, making separation and identification difficult. 2. Column Degradation: Catalysts or reaction products can sometimes degrade the stationary phase, affecting the columnâs lifespan and performance. 3. Solvent Compatibility: Some catalytic reactions involve solvents or conditions that are not compatible with common HPLC setups.
