1. Harsh Reaction Conditions: High temperatures, pressures, and corrosive environments can damage sensors or affect their accuracy. 2. Spatial Constraints: Limited space within the reactor can make it difficult to place sensors without interfering with the reaction. 3. Dynamic Reactions: Reactions that involve rapid changes in conditions require sensors that can quickly and accurately respond to these changes. 4. Calibration and Maintenance: Ensuring sensors are correctly calibrated and maintained without interrupting the catalytic process can be challenging.