1. Reactor Design: Choosing the right type of reactor is crucial. The reactor used in the lab may not be suitable for large-scale production. 2. Heat Transfer: Maintaining optimal temperature is more challenging at a larger scale. 3. Mass Transfer: Efficient mixing and contact between reactants and the catalyst can be problematic. 4. Catalyst Deactivation: Over time, catalysts may lose their activity, and this issue can be more pronounced at a larger scale.
