What are the Challenges in Carbene Transfer Reactions?
Despite their utility, carbene transfer reactions pose several challenges:
- Reactivity Control: Carbenes are highly reactive and can lead to side reactions or decomposition if not properly controlled. - Selectivity: Achieving high regio- and stereoselectivity in carbene transfer reactions is often challenging, requiring precise catalyst design and reaction conditions. - Stability of Catalysts: Some metal-carbene complexes can be unstable, leading to catalyst deactivation. Research is ongoing to develop more robust catalytic systems.
