Despite advancements, several challenges persist in the field of catalytic C-C bond formation:
1. Selectivity: Achieving high regioselectivity and stereoselectivity can be difficult, especially in complex molecules. 2. Reactivity: Some substrates are less reactive or incompatible with existing catalytic systems. 3. Sustainability: The use of precious metals like palladium raises concerns about cost and environmental impact, driving the search for more sustainable alternatives.
