What Are Some Examples of Pharmacogenomic Variations?
One well-known example is the CYP2D6 enzyme, which metabolizes approximately 25% of all prescription drugs. Variations in the CYP2D6 gene can classify individuals into poor, intermediate, extensive, or ultra-rapid metabolizers. Another example is the TPMT enzyme, which is crucial for the metabolism of thiopurine drugs used in treating leukemia and autoimmune diseases. Genetic testing for TPMT can prevent severe toxicity in patients.