What are Some Common Methods in Enantioselective Catalysis?
Several methods have been developed to achieve enantioselective synthesis through catalysis:
- Asymmetric Hydrogenation: This involves the addition of hydrogen to a substrate in the presence of a chiral catalyst, often a metal complex with chiral ligands. - Asymmetric Epoxidation: This process forms an epoxide from an alkene using a chiral catalyst, such as the Sharpless epoxidation which employs titanium-tartrate complexes. - Asymmetric Dihydroxylation: Another method developed by K. Barry Sharpless, this involves the addition of hydroxyl groups to a double bond, using a chiral osmium catalyst.
