Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of pharmacological inhibitors that target enzymes involved in a cellular process known as DNA repair. These enzymes, particularly PARP1, play a significant role in repairing single-strand breaks in DNA. By inhibiting PARP, these compounds can induce cell death in cancer cells that already have a compromised ability to repair DNA, such as those with BRCA mutations.
