The Krebs Cycle is tightly regulated to meet the energy demands of the cell. Key regulatory points include:
- Allosteric Regulation: Enzymes like isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase are regulated by allosteric effectors such as ATP, ADP, NADH, and NAD+. - Substrate Availability: The availability of substrates like acetyl-CoA and oxaloacetate can influence the rate of the cycle. - Product Inhibition: Accumulation of products like NADH and ATP can inhibit enzyme activity, providing feedback control.
