The activation of S6K1 is primarily regulated by the mTOR signaling pathway. mTORC1 (mTOR complex 1) phosphorylates and activates S6K1 in response to various stimuli, including nutrients, growth factors, and cellular energy status. Upon activation, S6K1 undergoes a series of phosphorylation events that enhance its catalytic activity, allowing it to phosphorylate downstream targets.
