DNMT activity is regulated at multiple levels. Post-translational modifications such as phosphorylation, ubiquitination, and acetylation can alter enzyme activity. Additionally, DNMTs interact with various proteins, including transcription factors and histone modifiers, to ensure that methylation occurs at the correct genomic locations. Inhibitors and small molecules can also modulate DNMT activity, providing potential therapeutic avenues for diseases associated with abnormal methylation.
