Diastereoselectivity in catalytic reactions is often achieved through the careful design of the catalyst and reaction conditions. Key strategies include:
- Chiral Catalysts: Using chiral catalysts that can induce diastereoselectivity by creating a chiral environment around the reaction center. - Ligand Design: Designing ligands that can selectively stabilize one diastereomer over others. - Substrate Control: Employing substrates that inherently favor the formation of one diastereomer. - Reaction Conditions: Optimizing temperature, solvent, and other reaction conditions to favor the desired diastereomer.
