gpihbp1 contributes to catalysis by interacting directly with LPL. This interaction is vital for the proper localization and function of LPL, which is an enzyme responsible for the catalytic breakdown of triglycerides into free fatty acids and glycerol. By binding to LPL, gpihbp1 ensures that LPL is correctly positioned at the endothelial surface of capillaries, where it can effectively access its substrate, the triglycerides.