Catalysis in the Suzuki Reaction primarily involves the use of a palladium catalyst. The catalytic cycle generally consists of three main steps: oxidative addition, transmetalation, and reductive elimination.
1. Oxidative Addition: The palladium catalyst undergoes oxidative addition with the organohalide, forming a palladium complex. 2. Transmetalation: The boronic acid then reacts with the palladium complex, transferring the organic group to the palladium center. 3. Reductive Elimination: Finally, the new carbon-carbon bond is formed through reductive elimination, regenerating the palladium catalyst for another cycle.
