How Does Catalysis Play a Role in Overcoming These Challenges?
Advances in catalysis are being leveraged to develop more effective NRTIs with improved selectivity and reduced side effects. Computational methods and high-throughput screening are used to design and test new compounds that can more effectively inhibit reverse transcriptase. Enzyme kinetics studies also help in understanding how different inhibitors interact with the enzyme, providing insights that can guide the optimization of drug candidates.
