A glovebox typically has two main components: the main chamber and the antechamber. The main chamber is where the manipulation of materials occurs, and it is equipped with built-in gloves that allow the user to handle materials inside the box without breaching the sealed environment. The antechamber acts as a transitional area where materials can be introduced or removed without exposing the main chamber to the outside atmosphere.
To maintain an inert atmosphere, the glovebox is purged with an inert gas, and an oxygen and moisture removal system is employed. This usually involves the use of catalytic converters and desiccants to scrub oxygen and moisture from the internal atmosphere.