How Do Mutations in Catalytic Enzymes Cause Genomic Instability?
Mutations in the genes encoding catalytic enzymes can impair their function. For example, mutations in the BRCA1 or BRCA2 genes, which are involved in DNA repair, can lead to an accumulation of DNA damage. Similarly, mutations in polymerase-δ or polymerase-ε can introduce replication errors, contributing to genomic instability.
