The activity of mitochondrial enzymes is tightly regulated to maintain cellular energy homeostasis. Regulation occurs through various mechanisms, including:
- Allosteric Regulation: Enzymes like ATP synthase can be regulated by molecules that bind to sites other than the active site, altering its activity. - Post-Translational Modifications: Enzymes can be modified by phosphorylation, acetylation, or ubiquitination, which can either activate or inhibit their activity. - Feedback Inhibition: Accumulation of ATP or other intermediates can inhibit enzymes involved in its production, preventing overproduction.
