How Can the Selectivity and Efficiency be Improved?
Selectivity and efficiency in Friedel-Crafts reactions can be improved through various strategies:
Using more sophisticated catalysts such as zeolites or metal-organic frameworks (MOFs) that offer better control over the reaction environment. Employing solvents that stabilize the carbocation intermediate. Using protecting groups to prevent polysubstitution. Opting for derivatives like Friedel-Crafts acylation, which typically offers better control over the reaction.
