1. Substitution: Replacing toxic or highly reactive chemicals with safer alternatives whenever possible. 2. Containment: Using closed systems and proper ventilation to minimize exposure. 3. Personal Protective Equipment (PPE): Ensuring that lab personnel wear appropriate PPE like gloves, goggles, and lab coats. 4. Training: Regular training on the safe handling, storage, and disposal of hazardous chemicals. 5. Emergency Preparedness: Having emergency protocols in place, including spill kits and eyewash stations.