While globe valves offer many advantages, there are some potential drawbacks to consider: 1. Flow Resistance: The tortuous flow path in globe valves can create a significant pressure drop, which may not be desirable in some applications. 2. Size and Weight: Globe valves are typically larger and heavier than other types of valves, which may be a consideration in space-constrained installations. 3. Cost: Due to their complex design and robust construction, globe valves can be more expensive than simpler valve types, such as ball valves.