Ligase reactions are vital for maintaining the integrity of genetic information. During DNA replication, DNA ligases seal nicks in the DNA backbone, ensuring that the newly synthesized DNA strands are continuous. This process is essential for the accurate transmission of genetic information from one generation to the next. In protein synthesis, aminoacyl-tRNA synthetases ensure that the correct amino acids are incorporated into growing polypeptide chains, which is crucial for the proper functioning of proteins.
