Understanding the catalytic mechanisms of cholesterol esterification has led to the development of therapeutic strategies:
1. ACAT Inhibitors: Drugs that inhibit ACAT can reduce the formation of cholesterol esters, potentially lowering the risk of atherosclerosis. Avasimibe is one such inhibitor that has been studied for its therapeutic potential. 2. Gene Therapy: Targeting the genes encoding ACAT1 and ACAT2 could provide new avenues for treating cholesterol-related disorders by modulating enzyme activity.
