How Can Catalysis Help in Diagnosing Megaloblastic Anemia?
Diagnostic approaches for megaloblastic anemia often involve assessing the activity of specific enzymes that require vitamin B12 or folate as cofactors. For instance, elevated levels of homocysteine and methylmalonic acid in the blood can indicate a vitamin B12 deficiency. These metabolites accumulate when the catalytic activity of methionine synthase and methylmalonyl-CoA mutase, respectively, is impaired. Similar diagnostic markers can be used to detect folate deficiencies, aiding in the accurate diagnosis and management of the condition.
