Thymidylate Synthase (ts) - Catalysis

Relevant Publications

Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights.

Issue Release: 2024

Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer.

Issue Release: 2024

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Agents.

Issue Release: 2024

Synthesis and anticancer evaluation of diaryl pyrido[2,3-d]pyrimidine /alkyl substituted pyrido[2,3-d]pyrimidine derivatives as thymidylate synthase inhibitors.

Issue Release: 2024

The function and mechanism of circRNAs in 5-fluorouracil resistance in tumors: Biological mechanisms and future potential.

Issue Release: 2024

An insight into thymidylate synthase inhibitor as anticancer agents: an explicative review.

Issue Release: 2024

Novel mass spectrometry-based assay for thymidylate synthase activity.

Issue Release: 2024

folA thyA knockout E. coli as a suitable surrogate model for evaluation of antifolate sensitivity against PfDHFR-TS.

Issue Release: 2024

Intersite communication in dimeric enzymes highlighted by structural and thermodynamic analysis of didansyltyrosine binding to thymidylate synthases.

Issue Release: 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity.

Issue Release: 2024

[Translated article] Genetic variants and enzyme activity in citidin deaminase: Relationship with capecitabine toxicity and recommendation for dose adjustment.

Issue Release: 2023

Activity of pemetrexed in pre-clinical chordoma models and humans.

Issue Release: 2023

Chalcone Mannich base derivatives: synthesis, antimalarial activities against , and molecular docking analysis.

Issue Release: 2023

A computational investigation of thymidylate synthase inhibitors through a combined approach of 3D-QSAR and pharmacophore modelling.

Issue Release: 2023

Antimalarial potential, LC-MS secondary metabolite profiling and computational studies of .

Issue Release: 2023

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects.

Issue Release: 2023

Mitochondria-Targeted Thymidylate Synthase Inhibitor Based on Fluorescent Molecularly Imprinted Polymers for Tumor Antimetabolic Therapy.

Issue Release: 2023

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection.

Issue Release: 2023

Association of Thymidylate Synthase () Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease.

Issue Release: 2023

1,3,4-Oxadiazoles as Anticancer Agents: A Review.

Issue Release: 2023

Why Do Catalysts Need to Be Regenerated?

What role do private organizations play in incentivizing catalysis research?

What Does a Catalyst Chemist Do?

Are There Funding Opportunities?

How does COPE support ethical publishing practices?

Why are Small Molecule Catalysts Important?

How Can Catalyst Life Be Extended?

Why is Mechanism Elucidation Important?

Why is Compounding Important?

How Does STED Work?

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