Thymidylate Synthase (ts) - Catalysis

Relevant Publications

Targeting CCR3 with antagonist SB 328437 sensitizes 5‑fluorouracil‑resistant gastric cancer cells: Experimental evidence and computational insights.

Issue Release: 2024

Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer.

Issue Release: 2024

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Agents.

Issue Release: 2024

Synthesis and anticancer evaluation of diaryl pyrido[2,3-d]pyrimidine /alkyl substituted pyrido[2,3-d]pyrimidine derivatives as thymidylate synthase inhibitors.

Issue Release: 2024

The function and mechanism of circRNAs in 5-fluorouracil resistance in tumors: Biological mechanisms and future potential.

Issue Release: 2024

An insight into thymidylate synthase inhibitor as anticancer agents: an explicative review.

Issue Release: 2024

Novel mass spectrometry-based assay for thymidylate synthase activity.

Issue Release: 2024

folA thyA knockout E. coli as a suitable surrogate model for evaluation of antifolate sensitivity against PfDHFR-TS.

Issue Release: 2024

Intersite communication in dimeric enzymes highlighted by structural and thermodynamic analysis of didansyltyrosine binding to thymidylate synthases.

Issue Release: 2024

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity.

Issue Release: 2024

[Translated article] Genetic variants and enzyme activity in citidin deaminase: Relationship with capecitabine toxicity and recommendation for dose adjustment.

Issue Release: 2023

Activity of pemetrexed in pre-clinical chordoma models and humans.

Issue Release: 2023

Chalcone Mannich base derivatives: synthesis, antimalarial activities against , and molecular docking analysis.

Issue Release: 2023

A computational investigation of thymidylate synthase inhibitors through a combined approach of 3D-QSAR and pharmacophore modelling.

Issue Release: 2023

Antimalarial potential, LC-MS secondary metabolite profiling and computational studies of .

Issue Release: 2023

Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects.

Issue Release: 2023

Mitochondria-Targeted Thymidylate Synthase Inhibitor Based on Fluorescent Molecularly Imprinted Polymers for Tumor Antimetabolic Therapy.

Issue Release: 2023

Delving in folate metabolism in the parasite Leishmania major through a chemogenomic screen and methotrexate selection.

Issue Release: 2023

Association of Thymidylate Synthase () Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease.

Issue Release: 2023

1,3,4-Oxadiazoles as Anticancer Agents: A Review.

Issue Release: 2023

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What Awards and Honors Has He Received?

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