Peptidomimetic Enzyme Inhibitors: - Catalysis

Relevant Publications

The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment.

Issue Release: 2024

Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.

Issue Release: 2024

Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter.

Issue Release: 2024

Development of New Peptidomimetic NADPH Oxidase Inhibitors with Antithrombotic Properties.

Issue Release: 2024

The Design, Synthesis and Mechanism of Action of Paxlovid, a Protease Inhibitor Drug Combination for the Treatment of COVID-19.

Issue Release: 2024

In-silico guided design, screening, and molecular dynamic simulation studies for the identification of potential SARS-CoV-2 main protease inhibitors for the targeted treatment of COVID-19.

Issue Release: 2023

Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL inhibitors against SARS-CoV-2.

Issue Release: 2023

Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria.

Issue Release: 2023

Disparate viral pandemics from COVID19 to monkeypox and beyond: a simple, effective and universal therapeutic approach hiding in plain sight.

Issue Release: 2023

3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived α-ketoamide inhibitor.

Issue Release: 2023

Discovery of pyrimidoindol and benzylpyrrolyl inhibitors targeting SARS-CoV-2 main protease (M) through pharmacophore modelling, covalent docking, and biological evaluation.

Issue Release: 2023

A critical study on acylating and covalent reversible fragment inhibitors of SARS-CoV-2 main protease targeting the S1-site with pyridine.

Issue Release: 2023

Scandium-44 Radiolabeled Peptide and Peptidomimetic Conjugates Targeting Neuropilin-1 Co-Receptor as Potential Tools for Cancer Diagnosis and Anti-Angiogenic Therapy.

Issue Release: 2023

Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination.

Issue Release: 2023

BACE-1 Inhibitors Targeting Alzheimer\'s Disease.

Issue Release: 2023

Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.

Issue Release: 2022

Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor.

Issue Release: 2022

Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.

Issue Release: 2022

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.

Issue Release: 2022

Identification of repurposing therapeutics toward SARS-CoV-2 main protease by virtual screening.

Issue Release: 2022

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What are Common Examples of Heterogeneous Catalysts?

What Types of IR Spectrophotometers are Used in Catalysis?

What is the Graduate Record Examination (GRE)?

How Do Co-Mo Catalysts Work?

How does catalysis benefit from MeDIP data?

What Qualities Should a Good Mentor Possess?

How Does Microwave Heating Work in Catalysis?

What are Thermostatted Reactors?

What are the Challenges in Catalyst Synthesis?

Peptidomimetic Enzyme Inhibitors: - Catalysis

Relevant Publications

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