Glycinamide Ribonucleotide Formyltransferase (garft) - Catalysis

Relevant Publications

Dual Template Molecularly Imprinted Polymers Targeting Blockade of CD47 for Enhanced Macrophage Phagocytosis and Synergistic Antimetabolic Therapy.

Issue Release: 2024

Molecular Factors Associated with Pemetrexed Sensitivity According to Histological Type in Non-small Cell Lung Cancer.

Issue Release: 2016

Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma.

Issue Release: 2013

Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer.

Issue Release: 2012

Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions.

Issue Release: 2012

Biomarker analysis in a phase III study of pemetrexed-carboplatin versus etoposide-carboplatin in chemonaive patients with extensive-stage small-cell lung cancer.

Issue Release: 2011

Establishment of pemetrexed-resistant non-small cell lung cancer cell lines.

Issue Release: 2011

TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed.

Issue Release: 2010

The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action.

Issue Release: 2010

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

Issue Release: 2009

Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence.

Issue Release: 2009

5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.

Issue Release: 2008

New data integrating multitargeted antifolates into treatment of first-line and relapsed non-small-cell lung cancer.

Issue Release: 2008

The depletion of cellular ATP by AG2034 mediates cell death or cytostasis in a hypoxanthine-dependent manner in human prostate cancer cells.

Issue Release: 2007

Derivation and characterization of a monoclonal antibody against human glycinamide ribonucleotide formyltransferase.

Issue Release: 2006

Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.

Issue Release: 2005

Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells.

Issue Release: 2005

Translational research with pemetrexed in breast cancer.

Issue Release: 2004

Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.

Issue Release: 2003

Deaza analogs of folic acid as antitumor agents.

Issue Release: 2003

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Glycinamide Ribonucleotide Formyltransferase (garft) - Catalysis

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