Deubiquitinating Enzymes (dubs) - Catalysis

Relevant Publications

USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells.

Issue Release: 2024

USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein.

Issue Release: 2024

Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway.

Issue Release: 2024

Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation.

Issue Release: 2024

Unveiling the Pharmacological Role of Human Deubiquitinating Enzymes in Temozolomide Response of Glioblastoma Cells.

Issue Release: 2024

Genome-wide identification and expression analysis of Ubiquitin-specific protease gene family in maize (Zea mays L.).

Issue Release: 2024

Targeting the ubiquitin pathway in lymphoid malignancies.

Issue Release: 2024

USP20 deubiquitinates and stabilizes the reticulophagy receptor RETREG1/FAM134B to drive reticulophagy.

Issue Release: 2024

De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features.

Issue Release: 2024

OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.

Issue Release: 2024

The Role of Deubiquitinating Enzymes in Primary Bone Cancer.

Issue Release: 2024

Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.

Issue Release: 2024

The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β.

Issue Release: 2024

USP26 promotes colorectal cancer tumorigenesis by restraining PRKN-mediated mitophagy.

Issue Release: 2024

N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.

Issue Release: 2024

Deubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response.

Issue Release: 2024

Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches.

Issue Release: 2024

Deubiquitinase USP47 ameliorates cardiac hypertrophy through reducing protein O-GlcNAcylation.

Issue Release: 2024

Super enhanced purification of denatured-refolded ubiquitinated proteins by ThUBD revealed ubiquitinome dysfunction in liver fibrosis.

Issue Release: 2024

DUBs in Alzheimer\'s disease: mechanisms and therapeutic implications.

Issue Release: 2024

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